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个人简介



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  • 性别：男
  • 职称：教授
  • 学历：博士
  • 学科：海洋科学
个人简历

1997年厦门大学微生物学专业毕业，获学士学位；同年免试推荐到中国科学院南海海洋研究所攻读海洋生物学硕士学位，于2000年获硕士学位；其后赴美国威廉玛丽学院攻读海洋科学博士学位，于2008年获博士学位；2008年起在美国弗吉尼亚海洋研究所开展博士后研究；2013年起聘为金沙9001cc以诚为本首页教授，博士生导师。2009年获美国威廉玛丽学院弗吉尼亚海洋研究所最佳博士生论文奖，2014年入选国家青年海外高层次人才引进计划。承担主持国家自然科学基金面上项目和广东省自然科学基金项目等。担任广东省优质环保水产养殖工程技术研究中心主任，中国水产学会鱼病专业委员会委员，中国水产学会《水产学报》编委，《Frontiers in Immunology》Review Editor。


教育经历
1997年厦门大学微生物学专业毕业，获学士学位；同年免试推荐到中国科学院南海海洋研究所攻读海洋生物学硕士学位，于2000年获硕士学位； 其后赴美国威廉玛丽学院攻读海洋科学博士学位，于2008年获博士学位
研究方向
以尼罗罗非鱼为研究材料，立足鱼类细胞及分子免疫学研究热点和前沿问题，结合免疫、细胞和分子生物学等手段重点开展如下研究： （1） B细胞功能调控机制及体液免疫记忆机制 鱼类B细胞具有类似专职吞噬细胞的吞噬功能，在免疫保护中发挥重要的作用。我们最近发现鱼类B细胞分化程度与其吞噬功能的强弱密切相关，并将开展鱼类B细胞吞噬功能的调控机制与演化规律研究。另外，我们初步阐明鱼类体液免疫记忆是由长寿命浆细胞和记忆性B细胞协同维持的。本研究方向将探究鱼类B细胞的功能调控和演化机制，旨在阐述B细胞功能的生物演化规律，深化硬骨鱼B细胞功能的调控理论体系。 （2） IgM抗体及补体分子结构和功能 鱼类IgM抗体具有四聚体同质异构体的结构多样性。我们最近研究发现硬骨鱼的免疫系统通过调控结合抗原的亲和力大小来改变分泌的IgM抗体同质异构体结构的比例，从而影响其抗体的生物学功能；并将开展其结构影响功能的调控机制及适应性进化机制。同时，开展补体系统关键分子参与抵御病原菌侵染的免疫应答的研究。 （3） 水产动物的健康养殖技术 通过研究微生物调控与免疫预防等绿色健康的病害防控技术，开展水产经济动物生态防治的健康养殖理论研究与技术研发。
讲授课程
《水产养殖理论与实践》，研究生，必修课 《鱼类免疫学》，研究生，选修课 《免疫学》，本科生，必修课 《现代仪器进展》，本科生，必修课
承担课题
国家自然基金面上项目(31972818)，主持 广东省农业农村厅重点项目(粤农2019A4)，主持 广东省海洋渔业厅重点项目(201701B04)，主持 广东省自然科学基金面上项目(2019A1515012065)，主持
论文专著

 

1.      Liting Wu, Shengli Fu, Xiaoxue Yin, Zheng Guo, Anli Wang, Jianmin Ye*. Long-lived plasma cells secrete high affinity antibodies responding to a T-dependent immunization in a teleost fish. 2019, Frontiers in Immunology. 02324. doi: 10.3389/fimmu.2019.02324.

2.      Liting Wu, Linghe Kong, Yanjian Yang, Xia Bian, Siwei Wu, Bingxi Li, Xiaoxue Yin, Liangliang Mu, Jun Li, Jianmin Ye*. Effects of cell differentiation on the phagocytic activities of IgM+ B cells in a teleost fish. 2019, Frontiers in Immunology. 02225. doi: 10.3389/fimmu.2019.02225.

3.      Enxu Zhou, Fangfang Yan, Bingxi Li, Meng Chen, Xiao Tu*, Siwei Wu, Hairong Wu, Xiufang Wei, Shengli Fu, Liting Wu, Zheng Guo, Jianmin Ye*. Molecular and functional characterization of IL-6 receptor (IL-6R) and glycoprotein 130 (gp130) in Nile tilapia (Oreochromis niloticus). 2020, Developmental and Comparative Immunology. 106, 103629.

4.      Yuan Li#, Bingxi Li#, Enxu Zhou, Shengli Fu, Yuhong Wang, Liting Wu, Yang Lei, Zheng Guo, Jianmin Ye*. CD38 plays roles in T cell-dependent response and B cell differentiation in Nile tilapia (Oreochromis niloticus). 2020, Developmental and Comparative Immunology. 103, 103515.

5.      Xiaoxue Yin, Liangliang Mu, Kailiang Han, Hairong Wu, Zheng Guo, Jianmin Ye*. Expression and functional analysis of Nile tilapia transferrin receptors (TfRs) in host resistance to pathogenic bacteria and iron ion metabolism. 2020, Fish and Shellfish Immunology. 100, 407-417.

6.      Liting Wu#, Along Gao#, Yang Lei, Jun Li, Kangsen Mai, Jianmin Ye*. SHP1 tyrosine phosphatase gets involved in host defense against Streptococcus agalactiae infection and BCR signaling pathway in Nile tilapia (Oreochromis niloticus). 2020, Fish and Shellfish Immunology. 99, 562-571.

7.      Yanjian Yang, Bingxi Li, Linghe Kong, Yuan Li, Xiaoxue Yin, Shengli Fu, Zheng Guo, Liting Wu*, Kangsen Mai, Jianmin Ye*. BAFF gets involved in response to bacterial infection and promotes IgM+ B cell survival in Nile tilapia (Oreochromis niloticus). 2020, Aquaculture. 522, 735113.

8.      Fangfang Yan, Enxu Zhou, Shuo Liu, Along Gao, Linghe Kong, Bingxi Li, Zheng Guo, Jinfeng Mo, Meng Chen*, Jianmin Ye*. Complement C1q subunit molecules from Xenopus laevis possess conserved function in C1q-immunoglobulin interaction. 2020, Developmental and Comparative Immunology. 103, 103532.

9.      Liting Wu, Yanjian Yang, Linghe Kong, Xia Bian, Zheng Guo, Shengli Fu, Fang Liang, Bingxi Li, Jianmin Ye*. Comparative transcriptome analysis of the transcriptional heterogeneity in different IgM+ cell subsets from peripheral blood of Nile tilapia (Oreochromis niloticus). 2019, Fish and Shellfish Immunology. 93, 612-622.

10.  Liangliang Mu, Hairong Wu, Kailiang Han, Liting Wu, Xia Bian, Bingxi Li, Zheng Guo, Xiaoxue Yin*, Jianmin Ye*. Molecular and functional characterization of a mannose-binding lectin/ficolin-associated protein (MAp44) from Nile tilapia (Oreochromis niloticus) involved in the immune response to bacterial infection. 2019, Developmental and Comparative Immunology. 101, 103438.

11.  Shengli Fu, Mingmei Ding, Haisu Liu, Liting Wu, Bingxi Li, Anli Wang, Shaoan Liao*, Jianmin Ye*. Identification and characterization of caspase-7 in pufferfish (Takifugu obscurus) in response to bacterial infection and cell apoptosis. 2019, Aquaculture. 512, 73426.

12.  Liangliang Mu, Xiaoxue Yin, Hairong Wu, Kailiang Han, Liting Wu, Mingmei Ding, Xia Bian, Bingxi Li, Shengli Fu, Fang Liang, Zheng Guo, Jianmin Ye*. Expression and functional characterization of a mannose-binding lectin associated serine protease-1 (MASP-1) from Nile tilapia (Oreochromis niloticus) in host defense against bacterial infection. 2019, Fish and Shellfish Immunology. 91, 68-77.

13.  Shengli Fu, Mingmei Ding, Qingjian Liang, Yanjian Yang, Meng Chen, Xiufang Wei, Anli Wang, Shaoan Liao∗, Jianmin Ye*. The key differentially expressed genes and proteins related to immune response in the spleen of pufferfish (Takifugu obscurus) infected by Aeromonas hydrophila. 2019, Fish and Shellfish Immunology. 91, 1-11.

14.  Liting Wu, Enxu Zhou, Along Gao, Linghe Kong, Siwei Wu, Xia Bian, Yuan Li, Bingxi Li, Shengli Fu, Zheng Guo∗ , Jianmin Ye*. Blimp-1 is involved in B cell activation and maturation in Nile tilapia (Oreochromis niloticus). 2019, Developmental and Comparative Immunology. 98, 137-147.

15.  Liting Wu, Along Gao, Linghe Kong, Siwei Wu, Yanjian Yang, Xia Bian, Zheng Guo, Yuan Li, Bingxi Li, Xunbin Pan, Jianmin Ye*. Molecular characterization and transcriptional expression of a B cell transcription factor Pax5 in Nile tilapia (Oreochromis niloticus). 2019, Fish and Shellfish Immunology. 90, 165-172.

16.  Liting Wu, Xia Bian, Linghe Kong, Xiaoxue Yin, Liangliang Mu, Siwei Wu, Along Gao, Xiufang Wei, Zheng Guo, Jianmin Ye*. B cell receptor accessory molecule CD79 gets involved in response against Streptococcus agalactiae infection and BCR signaling in Nile tilapia (Oreochromis niloticus). 2019, Fish and Shellfish Immunology. 87, 212-219.

17.  Liting Wu, Shengli Fu, Xiaoxue Yin, Wenna Leng, Zheng Guo, Anli Wang, Jianmin Ye*. Affinity maturation occurs in channel catfish (Ictalurus punctaus) following immunization with a T-cell dependent antigen. 2019, Fish and Shellfish Immunology. 84, 781-786.

18.  Xiaoxue Yin, Liangliang Mu, Shengli Fu, Liting Wu, Kailiang Han, Hairong Wu, Xia Bian, Xiufang Wei, Zheng Guo, Anli Wang, Jianmin Ye*. Expression and characterization of Nile tilapia (Oreochromis niloticus) secretory and membrane-bound IgM in response to bacterial infection. 2019, Aquaculture. 508, 214-222.

19.  Xiaoxue Yin, Yanjian Yang, Kailiang Han, Liting Wu, Hairong Wu, Xia Bian, Xiufang Wei, Zheng Guo, Liangliang Mu*, Jianmin Ye*. Purification and functional characterization of serum transferrin from Nile tilapia (Oreochromis niloticus). 2019, Fish and Shellfish Immunology. 88, 36-46.

20.  Xia Bian, Siwei Wu, Xiaoxue Yin, Liangliang Mu, Fangfang Yan, Linghe Kong, Zheng Guo, Liting Wu*, Jianmin Ye*. Lyn is involved in host defense against S. agalactiae infection and BCR signaling in Nile tilapia (Oreochromis niloticus). 2019, Developmental and Comparative Immunology. 96, 1-8.

21.  Liangliang Mu, Xiaoxue Yin, Yanjian Yang, Liting Wu, Hairong Wu, Bingxi Li, Zheng Guo, Jianmin Ye*. Functional characterization of a mannose-binding lectin (MBL) from Nile tilapia (Oreochromis niloticus) in non-specific cell immunity and apoptosis in monocytes/macrophages. 2019, Fish and Shellfish Immunology. 87, 265-274.

22.  Meng Chen, Shuo Liu, Fangfang Yan, Enxu Zhou, Xiaofang Zhong, Mingmei Ding, Jianmin Ye*. Complement 1q-binding protein from Nile tilapia (Oreochromis niloticus): Molecular characterization, expression pattern upon bacterial infection and its binding properties. 2019, Aquaculture. 500, 31-40.

23.  Xiaoxue Yin, Liangliang Mu, Yuan Li, Liting Wu, Yanjian Yang, Xia Bian, Bingxi Li, Shaoan Liao, Yutao Miao, Jianmin Ye*. Identification and characterization of a B-type mannose-binding lectin from Nile Tilapia (Oreochromis niloticus) in response to bacterial infection. 2019, Fish and Shellfish Immunology. 84, 91-99.

24.  Shuo Liu, Meng Chen, Fangfang Yan, Enxu Zhou, Bingxi Li, Shengli Fu, Xiaoxue Yin, Zheng Guo, Jianmin Ye*. Expression and functional analysis of polymeric immunoglobulin receptor in Nile tilapia (Oreochromis niloticus). 2019, Aquaculture. 500, 41-49.

25.  Jian-An Xian, Xiu-Xia Zhang, An-Li Wang, Jun-Tao Li, Pei-Hua Zheng, Yao-Peng Lu, Dong-Mei Wang*, Jianmin Ye*. Oxidative burst activity in haemocytes of the freshwater prawn Macrobrachium rosenbergii. 2018, Fish and Shellfish Immunology. 73, 272-278.

26.  Meng Chen, Mingmei Ding, Yuan Li, Xiaofang Zhong, Shuo Liu, Zheng Guo, Xiaoxue Yin, Shengli Fu, Jianmin Ye*. The complement component 1 q (C1q) in Nile tilapia (Oreochromis niloticus): Functional characterization in host defense against bacterial infection and effect on cytokine response in macrophages. 2018, Developmental and Comparative Immunology. 87, 98-108.

27.  Liangliang Mu, Xiaoxue Yin, Yanhui Xiao, Xia Bian, Yanjian Yang, Liting Wu, Jianmin Ye*. A C-type lectin (CL11X1-like) from Nile tilapia (Oreochromis niloticus) is involved in host defense against bacterial infection. 2018, Developmental and Comparative Immunology. 84, 230-240.

28.  Liangliang Mu, Xiaoxue Yin, Xia Bian, Liting Wu, Yanjian Yang, Xiufang Wei, Zheng Guo, Jianmin Ye*. Expression and functional characterization of collection-K1 from Nile tilapia (Oreochromis niloticus) in host innate immune defense. 2018, Molecular Immunology. 103, 21-34.

29.  Xiufang Wei, Bingxi Li, Liting Wu, Xiaoxue Yin, Xiaofang Zhong, Yuan Li, Yuhong Wang, Zheng Guo, Jianmin Ye*. Interleukin-6 gets involved in response to bacterial infection and promotes antibody production in Nile tilapia (Oreochromis niloticus). 2018, Developmental and Comparative Immunology. 89, 141-151.

30.  Xia Bian, Liting Wu, Liangliang Mu, Xiaoxue Yin, Xiufang Wei, Xiaofang Zhong, Yanjian Yang, Junru Wang, Yuan Li, Zheng Guo, Jianmin Ye*. Spleen tyrosine kinase from Nile tilapia (Oreochromis niloticus): Molecular characterization, expression pattern upon bacterial infection and the potential role in BCR signaling and inflammatory response. 2018, Fish and Shellfish Immunology. 82, 162-172.

31.  Xiaoxue Yin, Liangliang Mu, Xia Bian, Liting Wu, Bingxi Li, Jing Liu, Zheng Guo, Jianmin Ye*. Expression and functional characterization of transferrin in Nile tilapia (Oreochromis niloticus) in response to bacterial infection. 2018, Fish and Shellfish Immunology. 74, 530-539.

32.  Shengli Fu, Mingmei Ding, Yanjian Yang, Jingrong Kong, Yuan Li, Zheng Guo, Anli Wang*, Jianmin Ye*. Molecular cloning, characterization and expression analysis of caspase-6 in puffer fish (Takifugu obscurus). 2018, Aquaculture. 490, 311-320.

33.  Xiaofang Zhong, Meng Chen, Mingmei Ding, Meiqi Zhong, Bingxi Li, Yuhong Wang, Shengli Fu, Xiaoxue Yin, Zheng Guo, Jianmin Ye*. C1r and C1s from Nile tilapia (Oreochromis niloticus): Molecular characterization, transcriptional profiling upon bacterial and IFN-γ inductions and potential role in response to bacterial infection. 2017, Fish and Shellfish Immunology. 70, 240-251.

34.  Liangliang Mu, Xiaoxue Yin, Jing Liu, Liting Wu, Xia Bian, Yuhong Wang, Jianmin Ye*. Identification and characterization of a mannose-binding lectin from Nile tilapia (Oreochromis niloticus). 2017, Fish and Shellfish Immunology. 67, 244-253.

35.  Mingmei Ding, Meng Chen, Xiaofang Zhong, Yuhong Wang, Shengli Fu, Xiaoxue Yin, Zheng Guo, Jianmin Ye*. Identification and characterization of C1 inhibitor in Nile tilapia in response to pathogenic bacteria. 2017, Fish and Shellfish Immunology. 61, 152-162.

36.  Meng Chen, Mingmei Ding, Yuhong Wang, Xiaoxue Yin, Shengli Fu, Zheng Guo, Anli Wang*, Jianmin Ye*.Complement C1Q has a novel tetrameric structure in Nile tilapia (Oreochromis niloticus). 2016, Fish and Shellfish Immunology. 53, 102-103.

37.  Liting Wu, Shengli Fu, Xiaoxue Yin, Zheng Guo, Anli Wang*, Jianmin Ye*. Long-lived plasma cells secret antibodies possessing high affinity in channel catfish. 2016, Fish and Shellfish Immunology. 53, 75.

38.  Jianmin Ye, Ilsa Kaattari, Cuiyan Ma, Stephen Kaattari*. The teleost humoral immune response. 2013, Fish and Shellfish Immunology. 36, 1719-1728.

39.  Cuiyan Ma*, Jianmin Ye *, Stephen Kaattari. Differential compartmentalization of memory B cells versus plasma cells in salmonid fish. 2013, European Journal of Immunology. 43, 360-370.

40.  Jianmin Ye, Ilsa Kaattari, Stephen Kaattari*. Plasmablasts and plasma cells: reconsidering teleost immune system organization. 2011, Developmental and Comparative Immunology. 35, 1273-1281.

41.  Jianmin Ye, Ilsa Kaattari, Stephen Kaattari*. The differential dynamics of antibody subpopulation expression during affinity maturation in a teleost. 2011, Fish and Shellfish Immunology. 30, 372-377.

42.  Jianmin Ye, Erin Bromage, Ilsa Kaattari, Stephen Kaattari*. Transduction of binding affinity by B lymphocytes: a new dimension in immunological regulation. 2011, Developmental and Comparative Immunology. 35, 982-990.

43.  Jianmin Ye, Erin Bromage, Stephen Kaattari*. The strength of B cell interaction with antigen determines the degree of IgM disulfide polymerization. 2010, Journal of Immunology. 18, 844-850.


附加信息

研究生获奖情况：

l  2019 国家奖学金 木亮亮、孔令贺、高阿龙

l  2018 国家奖学金 边霞、魏秀芳

l  2017 国家奖学金 仲小芳

l  2016 国家奖学金 陈萌

l  2015 国家奖学金 尹晓雪、付胜利

l  2019 广东省优秀研究生毕业生 边霞

l  2019 金沙9001cc以诚为本首页优秀研究生毕业生 吴丽婷

l  2019 曾永裕奖学金 吴丽婷

l  2018 广东省研究生学术论坛一等奖 吴丽婷

l  2016第二届鱼类与贝类免疫学国际会议 Travel Grant吴丽婷

 

招聘启事:

1. 根据课题组发展需要，诚聘具有鱼类免疫学、鱼类遗传育种研究背景、或具有水产经济动物免疫学和病害控制研究基础的博士后或青年英才1-2名，待遇从优，招聘详情请见金沙9001cc以诚为本首页人事处信息;

2. 根据课题组发展需要，长期招收有志于鱼类细胞与分子免疫学研究的硕士研究生（动物学、水产学）和博士研究生（动物学、生态学）。


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